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Tennessee Plant Research Center    

Andreas Nebenführ, Ph.D.

Department of Biochemistry and CellularAndreas Nebenführ
and Molecular Biology

Office: Hesler Biology 240
Phone: (865) 974-9201
email: nebenfuehr@utk.edu


visit our lab website




Research

Research in the Nebenführ lab centers around intracellular transport processes. How do individual proteins or entire organelles reach the position in the cell where their specific function is required? Given the large size of plant cells, this is frequently an a difficult undertaking. At the same time, it is evident that proper localization of cellular components is essential for normal growth and development of plants. To address these fundamental questions, we are focusing on the role of myosin motor proteins in cytoplasmic streaming, a process that can rapidly deliver entire organelles to different parts of the cell. Of particular interest are tip growing cells (root hairs, pollen tubes) that combine rapid cytoplasmic streaming with highly polarized secretion. We are investigating the mechanisms of myosin action by a combination of approaches that employ molecular, biochemical, cell biological, and genetic tools.For more details, please see the publication list below or visit our lab website.

Root   orgMove

Flower

Publications

Li J, Nebenführ A (2008) Inter-dependence of dimerization and organelle binding in myosin XI. Plant Journal 55: 478-490.

Li J, Nebenführ A (2008) The tail that wags the dog: The globular tail domain defines the function of myosin V/XI. Traffic 9: 290-298.

Nebenführ A (2007) Organelle dynamics during cell division. in: Cell division control in plants. (Eds. Verma DPS and Hong Z). Plant Cell Monographs 9: 195-206.

Nelson B, Cai X, Nebenführ A (2007) A multi-color set of in vivo organelle markers for colocalization studies in Arabidopsis and other plants. Plant Journal 51: 1126-1136.

Li J, Nebenführ A (2007) Organelle targeting of myosin XI is mediated by two globular tail subdomains with separate binding sites. Journal of Biological Chemistry 282: 20593-20602.

Saint-Jore-Dupas C, Nebenführ A, Boulaflous A, Follet-Gueye ML, Plasson C, Hawes C, Driouich A, Faye L, Gomord V (2006) Plant N-glycan processing enzymes employ different targeting mechanisms for their spatial arrangement along the secretory pathway. Plant Cell 18: 3182-3200.

Hoffmann A, Nebenführ A (2004) Dynamic rearrangements of transvacuolar strands in BY-2 cells imply a role of myosin in remodeling the plant actin cytoskeleton. Protoplasma 224: 201-210.

Nebenführ A, Ritzenthaler C, Robinson DG (2002) Update on brefeldin A: deciphering an enigmatic inhibitor of secretion. Plant Physiology 130: 1102-1108.

Ritzenthaler C, Nebenführ A, Movafeghi A, Stussi-Garaud C, Behnia L, Pimpl P, Staehelin LA, and Robinson DG (2002) Reevaluation of the effects of brefeldin A on plant cells using tobacco BY-2 cells expressing Golgi-targeted GFP and COP I antisera. Plant Cell, 14: 237-161.

Nebenführ A and Staehelin LA (2001) Mobile factories: Golgi dynamics in plant cells. Trends in Plant Science 6:160-167.

Nebenführ A, Gallagher LA, Dunahay TG, Frohlick JA, Mazurkiewicz AM, Meehl JB, Staehelin LA (1999) Stop-and-go movements of plant Golgi stacks are mediated by the acto-myosin system. Plant Physiology 121: 1127-1141.


 

 


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