Brad Binder, Ph.D.
Department of Biochemistry and Cellular
and Molecular Biology
Office: 343 Hesler,
Lab: 106 Hesler, (865) 974-7997
Visit our lab website
Research in the Binder lab focuses on ethylene signal transduction. One areaof research is on the structure and function of the ethylene binding domain. Some of our goals with this are to characterize the ethylene binding pocket and define the conformational changes that occur when ethylene binds to the receptor. Another focus is on the signal output of the receptors. While the receptors have been shown to have protein kinase activity, this activity is not crucial for receptor function. Thus, we are working towards defining the output of the receptors. A third focus is on better defining components down-stream of the receptors and interactions with other hormone signaling pathways. Finally, we are examining the evolution of ethylene receptors. It is believed that these receptors were acquired during the endosymbiotic event that led to chloroplasts. We are now studying putative ethylene receptors in various cyanobacteria. To pursue these projects we combine biochemistry, molecular biology, genetics and physiology. For more details about this research visit my Lab Page.
Chen Y-F, Gao Z, Kerris RJ, Wang W, Binder BM, Schaller GE (2010) Ethylene Receptors Function as Components of High-Molecular-Mass Protein Complexes in Arabidopsis. PLoS ONE. 5:e8640. doi:10.1371/journal.pone.0008640. [Article]
Binder BM and Patterson SE (2009) Ethylene-dependent and –independent regulation of Abscission. Stewart Postharvest Review. 5(1): 1-10.
Schotsmans WC, Prange RK, Binder BM (2009) 1-Methylcyclopropene: Mode of Action and Relevance in Postharvest Horticultural Research. Horticultural Reviews 35: 263-313.
Binder BM (2008). The Ethylene Receptors: Complex perception for a simple gas. Plant Science. 175: 8-17.
Gao Z, Wen C-K, Binder BM, Chang J, Chiang Y-H, Kerris III RJ, Chang C, Schaller GE. (2008). Heteromeric Interactions Among Ethylene Receptors of Arabidopsis. Journal of Biological Chemistry 283: 23801-23810. [Abstract]
Pirrung MC, Bleecker AB, Inoue Y, Rodriguez FI, Sugawara N, Wada T, Zou Y, Binder BM. (2008) Ethylene Receptor Antagonists: Strained Alkenes Are Necessary But Not Sufficient. Chemistry and Biology 15: 313-321. [Abstract]
Binder BM, Rodriguez FI, Bleecker AB, Patterson SE. (2007) The Effects of Group 11 Transition Metals, Including Gold, on Ethylene Binding to the ETR1 Receptor and Growth of Arabidopsis thaliana. FEBS Letters 581: 5105-5109. [Abstract]
Binder BM, Walker JM, Gagne JM, Emborg TJ, Hemmann G, Bleecker AB, Vierstra RD. (2007) The Arabidopsis EIN3-Binding F-Box Proteins, EBF1 and 2 Have Distinct but Overlapping Roles in Regulating Ethylene Signaling. The Plant Cell 19: 509-523. [Abstract]
Binder BM (2007) Rapid Kinetic Analysis of Ethylene Growth Responses in Seedlings: New Insights into Ethylene Signal Transduction. Journal of Plant Growth Regulation. 26: 131-142.
Schaller, GE, Binder BM (2007) Biochemical Characterization of Plant Ethylene Receptors Following Transgenic Expression in Yeast. IN: Two-Component Signaling Systems, Part A. Methods in Enzymology. Academic Press. (M. Simon, B. Crane, A. Crane, eds.) Volume 422: 270-287.
Wang W, Esch JE, Shiu S-H, Agula H., Binder BM, Chang C, Patterson SE, Bleecker AB. (2006) Identification of Important Regions for Ethylene Binding and Signaling in the Transmembrane Domain of the ETR1 Ethylene Receptor of Arabidopsis The Plant Cell 18: 3429-03442. [Article]